An HLA (human leukocyte antigen) disease association is defined as a statistically increased frequency of the HLA haplotype in individuals with the disease compared to the frequency in individuals without the disease. HLA-B27 has been associated with over 100 diseases, including many ocular diseases and systemic diseases with ocular manifestations. The first HLA haplotype association with inflammatory disease correlated HLA-B27 with ankylosing spondylitis, which remains one of the strongest known associations of disease with HLA-B27.
HLA typing is also important for solid organ and bone marrow transplants, disease association studies, and vaccine development and application.
HLA tests offered by the Northwell Health Genomics Alliance include:
Commonly Ordered Tests