Hereditary Cancer Syndromes

Most cancer is not hereditary; however, some individuals develop cancer as a result of a harmful mutation, also known as a pathogenic variant, in a gene that can be passed down from generation to generation. Overall, inherited mutations are thought to play a role in about 5-10% of all cancers. Mutations in specific genes are often associated with increased cancer risks in specific tumor types. It is estimated that approximately 5-10% of breast cancer, 5% of colorectal cancer, and up to 25% of ovarian cancer is due to a pathogenic variant associated with hereditary cancer susceptibility.

Through the Northwell Health Genomics Alliance, hereditary cancer genetic testing panel options are available based on both tumor site and genetic risk level. Commonly ordered tests are listed below.


Commonly Ordered Tests



See All Tests for Hereditary Cancer Syndromes