Immunologic Disorders

Immunodeficiencies occur when part of the immune system does not function properly. The most common cause of immune deficiency worldwide is malnutrition; however, in developed countries, most immunologic deficiency disorders are caused by hereditary or genetic defects. These disorders are usually identified as recurrent or severe infections in very young children; however, the disorders can affect anyone, regardless of age or gender. Some immunologic disorders affect a single part of the immune system while others affect more than one component of the system.

Inherited immunologic disorders are caused by a defective gene, which helps us better understand the molecular basis of immune processes and provides us the necessary information for diagnosis and genetic counseling. The Northwell Health Genomics Alliance offers genetic testing for hereditary immunologic disorders. Commonly ordered tests are listed below:

Commonly Ordered Tests

• GD678 Hyper-IgE Syndromes Panel
• GD3123 Hyper-IgE syndrome, STAT3 Sequencing
• GD601 Comprehensive SCID Panel
• GD1435 Chronic Granulomatous Disease, NCF1 (Exon 2) Sequencing
• GD505 Wiskott Aldrich Syndrome, WAS Sequencing

See All Tests for Immunologic Disorders